Speaking of girly sweeties, boys always show evil smiles. In fact, in-game sweeties are not tender any more, but have begun to fight against the evil wielding huge weapons, some of whom are even terribly scaring.
Related Article
The 11 Scariest Babies in Videogames
Silent Hill 2: Laura
Laura is an eight-year old girl who appears in Silent Hill 2, and is often seen wandering around the town. She is the only innocent human character in the town who does not hold any darkness in her heart, in contrast to James Sunderland, Angela Orosco and Eddie Dombrowski, and consequently does not see any monsters or serious abnormalities in the town of Silent Hill, including Maria. (Source: http://silenthill.wikia.com/wiki/Laura)
BioShock: Little Sister
Little Sisters (originally named as Gatherers) are young girls who have been genetically altered and mentally conditioned to reclaim ADAM from the corpses around Rapture. Little Sisters are almost always accompanied by a Big Daddy. They are almost completely immune to damage and have no offensive abilities. Attacking them, however, will incur the wrath of their protectors. (Source: http://bioshock.wikia.com/wiki/Little_Sister)